How Laxogenin Can Improve Muscle Growth

What Is Laxogenin | Benefits | FAQs | Similar To Laxogenin | Popular Products | Stacks | Warnings And Side Effects | Disclaimer

Laxogenin, also known as 5a-Hydroxy Laxogenin or Laxo-100, has been generating buzz in the fitness world for its potential muscle-building properties. We first explored this intriguing natural compound back in 2016. However, research continues to evolve, and in this blog post, we’ll delve deep into the latest scientific insights on laxogenin and its connection to muscle growth.

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Section Divider: What Is Laxogenin

What Is Laxogenin?

Laxogenin, also known as 5α-Hydroxy Laxogenin or Laxo-100, is a naturally occurring plant steroid. It belongs to a unique group called brassinosteroids, which act as plant hormones promoting growth and development. It can be extracted from several plants, but the most common is Smilax sieboldii. This plant is very similar to asparagus. (1,2,3,4,5)

Some of the other plant sources include:

  • Allium chinense
  • Diosgenin

Similar to how human hormones influence our bodies, brassinosteroids play a crucial role in plant health. Their chemical structure shares similarities with cholesterol, a building block for testosterone in humans. This structural similarity sparks interest in the potential of brassinosteroids, like Laxogenin, to mimic some anabolic effects in humans (i.e., promoting muscle growth).†

Comparison Visual: Plant Sterols VS Human Steroids

Both plant sterols and testosterone stem from a common molecule called 5α-cholestane. However, their functionalities diverge significantly. Brassinosteroids are essential for plant growth, influencing processes like cell division, stem elongation, and enhanced protein synthesis. In contrast, human steroids encompass a wider range of functions, impacting metabolism, immune response, and sexual development.†

However, recent research has highlighted the potential anabolic properties of brassinosteroids in humans, suggesting they may promote muscle growth and strength gains without the common side effects associated with traditional anabolic steroids or prohormones. This distinction makes laxogenin products appealing to athletes and fitness enthusiasts who seek performance enhancement without needing post-cycle therapy (PCT).†

 However, it is important to check all compounds in the formula, as they may contain a DHEA-based prohormone.†

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Benefits Of Laxogenin:

While effects can vary from person to person, both customer reports and scientific studies have highlighted numerous potential benefits associated with laxogenin:

  • Aiding in Muscle Recovery: Many users report reduced muscle soreness and faster recovery times between workouts, which can support more frequent training sessions and overall performance improvement.†

  • Promoting an Increase in Protein Synthesis: This is crucial for muscle growth and repair, potentially enhancing the body’s ability to build and maintain muscle mass.†

  • May Have Adaptogenic Properties: Some evidence suggests laxogenin may act as an adaptogen, helping the body manage stress more effectively and supporting overall resilience.†

  • May Relieve Inflammation and Pain: Users have noted reduced inflammation and pain levels, particularly post-exercise, which can aid in recovery and comfort.†

  • Assisting in Fat Loss: While not a direct fat burner, some individuals have reported easier maintenance of a lean physique while using laxogenin supplements.†

  • Helping Reduce LDL “Bad” Cholesterol: Research indicates potential cardiovascular benefits, including a modest reduction in LDL cholesterol levels, which contributes to heart health.†

  • May Improve Thyroid Function: There’s some indication that laxogenin could support thyroid function, potentially influencing metabolism and energy levels positively.†

  • May Limit Protein Breakdown: By potentially reducing muscle protein breakdown, laxogenin may help preserve muscle mass during periods of calorie restriction or intense training.†

The broad spectrum of reported effects is noteworthy for a single ingredient, especially considering laxogenin’s non-hormonal nature. However, individual responses vary widely. While some users experience multiple benefits, others may not notice significant effects.

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Similar To Laxogenin:

Now, let’s get into the good stuff! Before committing to laxogenin, we must see how it compares to other compounds and products. 

These are two different things that are often confused. First things first, a prohormone will affect your hormones. Because of this, the effects are generally more powerful. But, you also carry a greater risk for side effects. Also, prohormones have to be cycled and followed by a PCT.†

You can read more about prohormones in our guide. This guide covers common prohormones, their effects, side effects, and PCTs.†

As we mentioned before, laxogenin will not affect your hormones. This is why it’s safe for men and women to take. While these prohormones and laxogenin are different compounds, it is common to see laxogenin featured in a prohormone formula. †

Because of the prohormones, you won’t notice the strength gains from laxogenin alone. However, for compounds that are more likely to “dry out” your joints, laxogenin can be a great addition to join support. And if you’re taking a prohormone that doesn’t feature laxogenin in the formula, you can stack them.†

Epicatechins are another plant-derived compound. More specifically, epicatechin is a flavonoid found in dark chocolate harvested from the cacao tree. So once again, it is non-hormonal and safe for both men and women to take.†

Why do we love epicatechin? For starters, it can increase nitric oxide in the body. You have your N.O. to thank when you’re in the gym and have a really good pump and maybe some vascularity gains.†

But, outside of aesthetics, this increase in N.O. means there’s an increase in blood flow (vasodilation). A vasoconstrictor is the opposite of a vasodilator; stimulants fall into this category. †

Why do we want vasodilation over vasoconstriction? An increase in blood flow means an increase in oxygen and nutrients, which ultimately means improved endurance, power, recovery, and growth.†

That alone is a great property. But it’s not the one Epicatechin is famed for. Epicatechin may also inhibit Myostatin and, therefore, up-regulate Follistatin.†

These are Myokines produced from your muscle cells. They work together in a ratio, Myostatin inhibits/suppresses muscle growth, while Follistatin increases it. So, by inhibiting Myostatin, you’re increasing your potential muscle growth.†

Laxogenin may boost nitrogen retention, but this effect isn’t something it’s known for. Instead, these compounds work very well together, so they work much better in a stack. If you’re looking for a more natural muscle-building stack, you can try the Women’s Muscle Building stack from Blackstone Labs (it’s not just for women). Or you can try stacking a laxogenin with a myostatin inhibitor like Epicat, Myostato, or Myo-stack.†

Adaptogens are plants that promote resistance to physical, chemical, or biological stressors. This means they can be hormonal, but not like a prohormone. An adaptogen can help reduce cortisol, the hormone the body releases when stressed.†

Cortisol has its purpose in the body, but when cortisol levels are too high, you can expect:

  • High blood pressure.
  • A flushed face.
  • Muscle weakness.
  • Increased thirst.
  • Urinating more frequently.
  • Changes in mood, such as feeling irritable or low.
  • Rapid weight gain
  • Osteoporosis.

And more. An adaptogen isn’t a miracle pill for anxiety and stress. It may help, but it won’t replace medication or therapy. Also, something to consider, different plants are going to have different effects. So one that boosts stamina (Cordyceps) and one that reduces stress and anxiety (Ashwagandha) are both still adaptogens.†

Laxogenin has adaptogenic properties; it can help reduce cortisol, but we wouldn’t classify it as an adaptogen. So if you want to build muscle and reduce cortisol, laxogenin is a great product for you. But it probably won’t be as noticeable as if you took an adaptogen with that purpose.†

Section Divider: Popular Products

Popular Products:

Here at Same Day Supplements, we currently carry three products as Laxogenin standalone. But there are a bunch of products and stacks that feature it in the formula.

Laxogenin 100 - Hi Tech Pharmaceuticals

How To Take Hi-Tech Pharmaceuticals Laxogenin 100:

The manufacturers recommend taking two (2) tabs daily.

Laxogenin 100 Review By Carter: “Love Laxogenin. Best natty product I’ve ever used and I take it 6 months out of the year! I always feel very positive on it and it does help put on a modest amount of size. Where it really shines I notice is my muscles get a lot harder on it and strength goes up pretty dramatically. This is the best brand for this product and it’s a great supplement. Highly recommend.”

Anogenin Supplement Facts

How To Take Blackstone Lab’s Anogenin:

The manufacturers recommend taking one (1) to two (2) capsules per day with food. They also suggest to use in cycles of 8-12 weeks with at least 4 weeks off in between cycles.

Anogenin Review By Rosa: “More lean and strength gone up. Looking better everyday.”

Laxogenin +

How To Take REPP Sports Laxogenin+:

The manufacturers recommend two (2) capsules daily with 8oz of water for men but suggest women take one (1) capsule daily with 8oz of water.

Laxogenin+ Review By Rory: “Only been using for two weeks, but I can already see growth, and seems to add a bit of endurance, also better recovery.”

Section Divider: Laxogenin Stacks


In addition to standalone use, stacking Laxogenin with other supplements can amplify its benefits for muscle growth and overall performance. Here are some effective stack options:

  • Hi-Tech Prohormone + Laxogenin Stack – 4 Week Cycle:
    This cutting-stack combination combines your choice of Hi-Tech Pharmaceuticals prohormones and Laxogenin, creating a synergy that maximizes muscle growth, strength gains, and performance enhancement.† Your chosen prohormone can assist in promoting rapid muscle development and enhancing athletic performance, complemented by the muscle-supporting properties of Laxogenin.†

  • Lipodrene Before and After Boost Kit:
    This unique kit includes two of Hi-Tech Pharmaceuticals’ most talked-about products: Lipodrene with Ephedra – 90 Tablets and Laxogenin 100 – 60 Tablets. Together, these supplements offer a supportive approach to your weight loss or muscle-building goals, providing a comprehensive solution for enhancing your physique and performance.†

  • Power of 3 Stack:
    Elevate your muscle-building potential and recovery with the Power of 3 Stack from Hi-Tech Pharmaceuticals.† This ultimate trio combines the anabolic strength of Laxogenin, the potent muscle support of Turkesterone 650, and the recovery-enhancing power of HMB to provide a comprehensive solution for advanced athletes and bodybuilders.†

  • The Natty Stack:
    Combining Hi-Tech Pharmaceuticals Laxogenin 100, Turkesterone 650, and Hi-Tech Fish Oil, the Natty Stack offers a balanced approach to muscle growth and overall health. Fish oil provides omega-3 fatty acids crucial for muscle function and cardiovascular health, enhancing the benefits of Laxogenin and Turkesterone in promoting recovery, joint health, and muscle growth.†

  • Other Stacking Options:
    For muscle-building, consider stacking Laxogenin with Halo Elite from Blackstone Labs. Halo Elite features a plant-derived androgen that enhances protein synthesis without affecting testosterone levels. Pairing Halo Elite with Laxogenin can create a potent muscle-building stack, with the addition of epicatechin for enhanced fat loss benefits. Laxogenin can be stacked with your favorite fat burner for fat loss goals. If you prefer a stimulant-free option, consider stacking it with supplements like Recomp-RX, CLA, L-Carnitine, or another stimulant-free blend to support your body composition goals effectively.†

Section Divider: Wrapping Up

†Please note the intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While we aim to maintain and display accurate information, we can’t guarantee it represents the latest product formula or information. Therefore, please visit the manufacturer’s website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturers’ and users’ views and information. Additionally, the Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent disease or illness.

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